DTG printers use aqueous textile inks (water-based chemistry) that require a unique curing process. Since D2 inks are water-based, they work best for printing on natural fibers such as cotton, bamboo, hemp, and linen. In addition, pre-treatment is typically applied to the garment before printing. The pre-treatment is heat-pressed into the custom t-shirt causing the fibers of the shirt to lay down.[2] The pre-treatment also allows the water-based inks to bond more fully to the garment. This is especially important when using white ink on dark garments.

Once the custom garment -for instance a t-shirt- has been properly pre-treated, the shirt (or garment) is then positioned onto a platten system designed to hold the shirt in place. The shirt is then digitally printed according to the design in the printer queue.